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The Best Marker for "Cholesterol" Risk

I belong to the International Network of Cholesterol Skeptics (THINCS). This group has been around since 2003 and is an on-line gathering place for clinicians, researchers and science writers who question the theory on cholesterol—that it contributes to heart disease, and that statins can help prevent heart attacks and strokes.


A wonderful bit of contradiction comes from the lofty towers of Harvard Medical School.

Harvard publishes a magazine called "Proto." Here is what Harvard says about their publication...

"Proto, a prefix of progress, connotes first, novel, experimental. Alone, it conjures an entire world of the new: discoveries, directions, ideas. In taking proto as its name, this magazine stakes its ground on medicine’s leading edge—exploring breakthroughs, dissecting controversies and opening a forum for informed debate."

Their May 20, 2021 article attacked the THINCS group for contributing "minority opinions" and Proto is boldly speaking out to keep this fringe group "from doing irreparable harm." (The link to this Proto article:

However, in 2011, Proto wrote quite the opposite as statin drugs were coming off of patent protection.

Which is it Mass General / Harvard - YOU CANNOT HAVE IT BOTH WAYS.

Thankfully the digital footprint is hard to erase, although Harvard has been guilty of this before. This is why I write content like this so when they try to eliminate it, I have the truth.

Here is an example of Harvard taking down valuable health information because of special interests:


What is the best marker?

It is the atherogenic index of plasma - AIP.

If you have not done lab tests with us then there is a 99.99% chance you have not heard about this marker.

The AIP is fundamental and understandable. It does not involve esoteric concepts that mean nothing to us like foam cells, little particle sizes, and intercalation into endothelium. Instead AIP is basically this.....

AIP is sugars divided by fats.

  • The bigger and more positive the AIP number, the greater your risk of dying young.

  • Sugars, being in the numerator make the AIP number go UP as sugars go up (in this case measured with triglycerides). That is, contribute to early mortality.

  • Fats, being in the denominator, make the AIP number go DOWN, as the fat value goes up. Fats are measured using HDL. HDL goes up as fat intake goes up - generally.

The actual AIP calculation and continuum of health based on this biomarker is:


Here is data from a Johns Hopkins group published in the Mayo Clinic Proceedings. A highly respected group indeed.

This is for people 65 and older. These people need fats more than young people because fats build cells and older people are breaking down faster - but the data really applies to everyone.

Notice that when total cholesterol is ABOVE 200, mortality goes DOWN.

Notice that when AIP is >0.24 mortality goes UP.

The ideal AIP is -0.36 or less (that is, less than zero). This obvious. You want you HDL to be about 60 and your triglycerides around 60. Here is the math done conveniently for me by

What is yours?

If your number is above 0.24, it is easy to lower it. Reduce sugar intake and increase fat intake. Of course, this means healthy fats and not those imposed upon us by the American Heart Association. Also, do not forget to take in non-digestible carbohydrates because we all must feed our microbiome.


Reference: "Atherogenic Index of Plasma and Triglyceride/ High-Density Lipoprotein Cholesterol Ratio Predict Mortality Risk Better Than Individual Cholesterol Risk Factors, Among an Older Adult Population."

Edwards, Meghan K., Michael J. Blaha, and Paul D. Loprinzi. "Atherogenic index of plasma and triglyceride/high-density lipoprotein cholesterol ratio predict mortality risk better than individual cholesterol risk factors, among an older adult population." Mayo Clinic Proceedings. Vol. 92. No. 4. Elsevier, 2017.

If you want a copy of the full paper, write to me and I will send it along..


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