"Cholesterol" is a U-Curve



Dr. Carter and I have several people in our program who have very LOW "cholesterol." As you know, if you listened to our talks on "cholesterol" that, when the medical industry says "cholesterol," they really mean LDL - or low density lipoprotein. The closest thing to LDL outside of the body is SOAP.


Soap carries fats (grease, oils) through water. Without soap, the fats are not soluble or miscible, and thus cannot be removed or moved by water alone. LDL and other lipoproteins (HDL as the other most common one), behave just like soap. They carry fat-soluble substances like: vitamin A, D, E, K, EPA, DHA, cholesterol, triglycerides and other fatty substances through your water-based blood stream. In other words, LDL and HDL are soaps.

The paper titled: Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults, shows that high mortality and disease occurs at either end of the "cholesterol" spectrum. This paper also shows that mortality and disease is much more pronounced at the low end, compared to the high end. In fact, the level that the American Heart Association considers optimal - and LDL < 70 mg/dL - is optimal - but not for good health - instead it is optimal for early death and disease.


https://www.nature.com/articles/s41598-018-38461-y

This paper was published in 2019

What is low "cholesterol?"

A key paper on this topic was published in 1993.

https://journals.lww.com/coronary-artery/citation/1993/10000/causes_of_hypocholesterolemia.3.aspx

It is old enough that it is not available as a text document so here are some screenshots.


***** NOTICE!! ***** This data is from our government !!!!

Several statement in this introduction stand out:

  • U-shaped association between blood cholesterol and subsequent mortality

  • The left side (low side) of this U represents increased mortality from cancer, pulmonary disease, digestive diseases, hemorrhagic stroke and accidental deaths (suicides are most predominant)

  • Cause for concern because it suggests outcomes of population interventions for cholesterol lowering that are opposite of intention


Possible causes of low cholesterol are:

  • statins

  • hyperthyroidism, or an overactive thyroid gland

  • adrenal insufficiency

  • liver disease

  • malabsorption (inadequate absorption of nutrients from the intestines), such as in celiac disease

  • malnutrition

  • abetalipoproteinemia - a rare genetic disease that causes cholesterol readings below 50 mg/dl.

  • It is found mostly in Jewish populations.

  • hypobetalipoproteinemia - a genetic disease that causes cholesterol readings below 50 mg/dl.

  • manganese deficiency

  • Smith–Lemli–Opitz syndrome

  • Marfan syndrome

  • leukemias and other hematological diseases

A paper titled, Hypolipidemia: A Word of Caution provides an overlapping list with more details....

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074286/


Anemia Hypocholesterolemia has been described in various types of chronic anemia [1217]. Few studies have suggested that such patients have a lower incidence of atherosclerosis associated events [12]. Types of anemia that have been reported to be associated with hypocholesterolemia include: congenital dyserythropoietic anemia [12], congenital spherocytosis [12, 13], sickle cell anemia [14], beta-thalassemia [