In this blog I am highlighting the work of Dr. Brian Balin.
I have been reading the works of Dr. Balin since his initial publication on Alzheimer's disease in 1998. That paper is titled,
Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain
The sad truth is Dr. Balin's work is being ignored. Here is a paper he published in 2018 - 20 years later.
Chlamydia pneumoniae: An Etiologic Agent for Late-Onset Dementia
Here is what the Alzheimer's Association has to say about Dr. Balin's work.
"No Results Found." Hmmm.... But what about the work of Dr. Balin. Not even a mention in a footnote? What should be front and center on their website "donate" or "explore chlamydia pneumoniae"?
As you can see, there are quite a few publications connecting AD and chlamydial infections.
If the two words are using in a search for articles in PubMed that contain both terms, here is the search results.
I think 14,400 results are sufficient to assert an association, especially in light of Dr. Balin's finding
Dr. Brian Balin:
Biography & Research:
Dr. Brian J. Balin is the Chairman and Professor of the Department of Bio-Medical Sciences at Philadelphia College of Osteopathic Medicine. In addition, Dr. Balin is the Director of the Center for Chronic Disorders of Aging, an Osteopathic Heritage Foundation endowed center, as well as the co-director of the Adolph and Rose Levis Foundation Laboratory for Alzheimer’s Disease Research at PCOM.
Dr. Balin is an internationally recognized expert in the field of Alzheimer's Disease research. His research interests include: Infection with Chlamydia pneumoniae as a trigger in the neuroinflammation and neurodegeneration in Alzheimer's Disease, effects of infection and inflammation on the blood brain barrier in cerebrovascular disease, modification of neuronal cytoskeletal proteins through phosphorylation and the action of transglutaminase, and pathogenesis of chronic disease associated with the aging process.
Dr. Balin has received numerous National Institutes of Health and private foundation grant awards for his research. He is highly published in peer-reviewed journals, and has written a number of chapters and reviews on the pathology of Alzheimer's disease, including reviews on the "Pathogen Hypothesis" of this disease (see live discussion section, www.alzforum.org). In addition, he has presented and continues to present his work at major national and international scientific meetings including a number of international and world congresses on Alzheimer's disease and related dementias.
Link to our video on stealth infections including the work of Dr. David Wheldon who reversed his wife's multiple sclerosis.
Here is the abstract from Dr. Balin's 2018 publication
The disease known as late-onset Alzheimer’s disease is a neurodegenerative condition recognized as the single most common form of senile dementia. The condition is sporadic and has been attributed to neuronal damage and loss, both of which have been linked to the accumulation of protein deposits in the brain.
Significant progress has been made over the past two decades regarding our overall understanding of the apparently pathogenic entities that arise in the affected brain, both for early-onset disease, which constitutes approximately 5% of all cases, as well as late-onset disease, which constitutes the remainder of cases.
Observable neuropathology includes: neurofibrillary tangles, neuropil threads, neuritic senile plaques and often deposits of amyloid around the cerebrovasculature. Although many studies have provided a relatively detailed knowledge of these putatively pathogenic entities, understanding of the events that initiate and support the biological processes generating them and the subsequent observable neuropathology and neurodegeneration remain limited. This is especially true in the case of late-onset disease.
Although early-onset Alzheimer’s disease has been shown conclusively to have genetic roots, the detailed etiologic initiation of late-onset disease without such genetic origins has remained elusive. Over the last 15 years, current and ongoing work has implicated infection in the etiology and pathogenesis of late-onset dementia.
Infectious agents reported to be associated with disease initiation are various, including several viruses and pathogenic bacterial species. We have reported extensively regarding an association between late-onset disease and infection with the intracellular bacterial pathogen Chlamydia pneumoniae.
In this article, we review previously published data and recent results that support involvement of this unusual respiratory pathogen in disease induction and development. We further suggest several areas for future research that should elucidate details relating to those processes, and we argue for a change in the designation of the disease based on increased understanding of its clinical attributes.
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