Is there a smoking gun between childhood vaccines, endocrine disruptors (thus hormone status), and Autism.
The MAPS people ARE aware of oxytocin. Here is a quote from one of their founders.
"Hands down (oxytocin is) one of the best interventions from my maps. Doctors have been prescribing it for a little over 10 years ago… used for social cognition improvement!
Has to be nasal from the right pharmacy."
"In addition to the increased tendency for infections in infants affected by endocrine disruptors, the immune response is also weakened. A Dutch study demonstrated that insufficient amounts of antibodies were formed following the measles-mumps-rubella vaccine in children exposed to PCB (21)."
"The COVID-19 infections cause impairment of endocrine organs, and similarly, the COVID-19 vaccinations also induce endocrine dysfunction. In this review, we summarize the influence of COVID-19 vaccines on the endocrine system, and explore the underlying pathogenic mechanisms.
Key points from our honest government.
All vaccines routinely recommended for children 6 years of age and younger in the U.S. are available in formulations that do not contain thimerosal.
Vaccines not containing thimerosal as a preservative are also available for adolescents and adults.
A robust body of peer-reviewed scientific studies conducted in the U.S. and other countries support the safety of thimerosal-containing vaccines.
Preservatives prevent microbial growth.
A preservative is required in multi-dose vials of vaccines.
The use of thimerosal as a preservative in vaccines has markedly declined due to the reformulation and development of new vaccines in single-use presentations.
From the year 2000 (Note: It is hard to find a publication from a U.S. source.)
Mercury, identified thousands of years ago, is one of the oldest toxicants known. The endocrine disruptive effects of mercury have recently become one of the major public concerns. In this report, the adverse effects of mercury on the hypothalamus, pituitary, thyroid, adrenal gland, and gonads (testis and ovary) in laboratory animals and humans are reviewed. The effects of both environmental and occupational exposures to organic, inorganic, or metallic mercury are explained. There is sufficient evidence from animal studies supporting the disruptive impacts of mercurials on the functions of the thyroid, adrenal, ovary, and testis.
The broad enzyme inhibition and the influence on hormone combining by their receptors, which seem due to its avid binding to sulphydryl, may account for the primary mechanism. Interference with intracellular calcium metabolism and peroxidation may also be involved.
From the year 2020
Thimerosal is ethyl mercury based compound which is being used as a preservative in vaccines since decades. Pharmaceutical products and vaccines that contain thimerosal are among the potential source of mercury exposure.
Thimerosal exposure resulted in a significant decrease in antioxidant enzyme activities including catalase (CAT), peroxidase (POD), superoxide dismutase (SOD), glutathione reductase (GSR) and increased levels of thiobarbituric acid reactive substances (TBARS).
Different doses of thimerosal significantly decreased (p < 0.05) the concentration of
plasma testosterone,
luteinizing hormone (LH) and
follicle stimulating hormone (FSH).
Additionally, Daily sperm production (DSP) and efficiency of daily sperm production were significantly reduced followed by thimerosal exposure.
Moreover, thimerosal significantly (p < 0.05) decreased the primary spermatocytes, secondary spermatocytes, number of spermatogonia along with spermatids.
From the year 2022
Abstract
Early exposure to mercury has been related to endocrine disruption. Steroid hormones play a crucial role in neural cell migration, differentiation, etc., as well as protecting against several neurotoxic compounds.
We investigate the relation between mercury exposure and children's sexual development, and we evaluate the possible influence of different brain-derived neurotrophic factor (BDNF) polymorphisms on this association.
Conclusions
In this Spanish birth cohort study we observed an inverse association between concurrent mercury concentrations and testosterone levels in both boys and girls. Additionally, we found that prenatal mercury was negatively associated with pubertal onset in boys.
Oxytocin may increase testosterone to compensate for the reduction of testosterone caused by vaccine ingredients.
Background
Oxytocin administration, which may be of therapeutic value for individuals with social difficulties, is likely to affect endogenous levels of other socially relevant hormones. However, to date, the effects of oxytocin administration on endogenous hormones have only been examined in neurotypical individuals. The need to consider multi-hormone interactions is particularly warranted in oxytocin trials for autism due to evidence of irregularities in both oxytocin and sex steroid systems.
Results
Distinct patterns of change in testosterone and estradiol levels pre- to-post-administration were observed in autistic relative to neurotypical women
Conclusions
This study provides the first evidence that oxytocin influences endogenous testosterone levels in autistic individuals, with autistic women showing increases similar to previous reports of neurotypical men. These findings highlight the need to consider sex steroid hormones as a variable in future oxytocin trials.
Background
Short-term manipulation of oxytocin is likely to influence endogenous release of other hormones expected to exert their own effects on social behaviour [6].
For example, increased testosterone levels have been reported in men [7, 8], but not in women [9], who received oxytocin nasal spray versus placebo.
Levels of arginine vasopressin, a neurohormone closely related to oxytocin, were found to increase in men and women following oxytocin administration [10].
Also in both sexes, the effects of oxytocin administration on parenting-related behaviours were found to depend on baseline endogenous testosterone levels [8, 11].
Notably, oxytocin and testosterone administration have shown opposing effects on various aspect of social behaviour in neurotypical populations and show opposite patterns of alteration in psychiatric conditions such as autism and schizophrenia [12], although such studies rarely assess multiple hormones within individuals.
References from this article:
6. Weisman O, Feldman R. Oxytocin administration affects the production of multiple hormones. Psychoneuroendocrinology. 2013;38:626–7.
7. Gossen A, Hahn A, Westphal L, Prinz S, Schultz RT, Gründer G, et al. Oxytocin plasma concentrations after single intranasal oxytocin administration - a study in healthy men. Neuropeptides. 2012;46:211–5.
8. Weisman O, Zagoory-Sharon O, Feldman R. Oxytocin administration, salivary testosterone, and father-infant social behavior. Prog Neuro-Psychopharmacology Biol Psychiatry. 2014;49:47–52.
9. Holtfrerich SKC, Pfister R, El Gammal AT, Bellon E, Diekhof EK. Endogenous testosterone and exogenous oxytocin influence the response to baby schema in the female brain. Sci Rep. 2018;8:1–10.
10. Weisman O, Schneiderman I, Zagoory-Sharon O, Feldman R. Salivary vasopressin increases following intranasal oxytocin administration. Peptides. Elsevier Inc.; 2013;40:99–103.
11. Holtfrerich SKC, Schwarz KA, Sprenger C, Reimers L, Diekhof EK. Endogenous testosterone and exogenous oxytocin modulate attentional processing of infant faces. PLoS One. 2016;11:1–19.
12. Crespi BJ. Oxytocin, testosterone, and human social cognition. Biol Rev. 2016;91:390–408.
Part 1
A substantial body of literature suggests that OXT has beneficial effects on brain function, particularly mood, empathy and anxiety. There is also consideration of its use in Autism. Could there be a connection between Autism, vaccines, and the delivery of endocrine disruptors?
Pardon me if this is well known. However, I am attending MedMaps next week and nothing on OXT came up when searching their site.
The MAPS people ARE aware of OXT. Here is a quote from one of their founders.
"Hands down (oxytocin is) one of the best interventions from my maps dr prescribed a little over 10 years ago… used for social cognition improvement!
Has to be nasal from the right pharmacy."
Here is the first paper I read on this topic, published in 1998.
Background: Social impairments are central to the syndrome of autism. The neuropeptide oxytocin (OT) has been implicated in the regulation of social behavior in animals but has not yet been examined in autistic subjects.
Methods: To determine whether autistic children have abnormalities in OT, midday plasma samples from 29 autistic and 30 age-matched normal children, all prepubertal, were analyzed by radioimmunoassay for levels of OT.
Results: Despite individual variability and overlapping group distributions, the autistic group had significantly lower plasma OT levels than the normal group.
OT increased with age in the normal but not the autistic children.
Elevated OT was associated with higher scores on social and developmental measures for the normal children, but was associated with lower scores for the autistic children. (Lewis - ???? Hmmm)
These relationships were strongest in a subset of autistic children identified as aloof.
Conclusions: Although inferring central OT functioning from peripheral measurements is difficult, the data suggest that OT abnormalities may exist in autism and that more direct investigation of central nervous system OT function is warranted.
A search of the medical literature shows that first paper on the relationship between OXT and autism was published in the early 1990s (at least when searching titles)
A deeper search (yes, I still rely on google for medical searches, at least using specific keywords - what choice do I have? ugh).
541 articles discuss the relationship between Autism and oxytocin - as determined by a title-only search. That means there are substantially more such articles.
This 2021 paper indicates that low OT IS prevalent in young Autism patients but ..
I intend to dig deeper into the positive and negative health effects of this interesting neuropeptide.
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