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Coronavirus: Hydroxychloroquine May be a Treatment.


The Motivation for Hydroxychloroquine
Quinine for Malaria - The motivation behind hydroxychloroquine

Update: There is evidence this drug will be effective against SARS-CoV-2 based on "in vitro" studies - and in humans. In vitro means outside the body in "culture" - a laboratory experiment.



Here is the scientific reference to the study being used to fast track the use of this drug.


https://www.mediterranee-infection.com/hydroxychloroquine-and-azithromycin-as-a-treatment-of-covid-19/


https://tinyurl.com/wzboo98. .

This link may not work. The title of the paper is:

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

 

Here is the Presidential announcement on the use of hydroxychloroquine.

https://youtu.be/TQDn_MwC-9I?t=138


 

It's interesting that this drug is an immunosuppressant that also is well demonstrated to treat malaria. Apparently it's mode of action isn't the same as the biologic immune suppressant drugs that are more likely to make this infection worse. Here is a link for those who enjoy rigorous scientific speak.

https://link.springer.com/article/10.1007/s12016-010-8243-x


Conclusion: I believe this drug has promise of effectiveness against the coronavirus because of its proven Antimicrobial Effects.


Hydroxychloroquine Antimicrobial Effects (taken from the article linked above)


In addition to its antimalarial effect, HCQ was found to be effective against bacterial and viral infections. Its antibacterial and antiviral effects are attributed to the alkalinization of intracellular acidic organelles infected by bacteria and to the inhibition of entry steps and viral proteins glycosylation. The most recognized antibacterial effect of HCQ is in Coxiella burnetii infections, where the treatment of choice for chronic Q-fever endocarditis consists of HCQ together with doxycycline for 18–36 months.

 

Comment from Dr. Lewis: Coxiella burnetii infection is commonly called Q-Fever. It is a virulent intracellular pathogen that we often test for. Why? Because it is at the root cause of many diseases - see list below. Importantly, the treatment for this bug is 12 - 36 month! This is not a 12 day dose of antibiotics - because these bugs live INSIDE cells and it takes a lot longer to get to and destroy them as a result.

 

Symptoms of Chronic Q Fever: Please read because many Americans have these symptoms but will never be tested for Q Fever.


Chronic Q fever may occur months to years after acute disease or may occur without a previous history of acute Q fever. Most cases of chronic Q fever occur in individuals with predisposing conditions such as existing heart valve or blood vessel (vascular) abnormalities or a compromised immune system.