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Focal Infection - What to Do? Part 3

In my last blog I presented a testimonial from a client who discussed how most dentists are no better than your regular doctor at understanding the concept of the health-disease continuum. This means they don't understand that even mild symptoms of poor oral hygiene, like gums that bleed when you floss, is an indication of periodontal disease that could be impacting your health NOW, and needs to be rectified.

Here is why even the slightest indication of periodontal disease must not be taken lightly. Consider this simple experiment.

Rub the back of your hand with a pencil eraser by applying strong pressure. If you continue to rub, your skin will become reddened and eventually will be bloody and painful. This is severe oral disease that may lead to pain, bone loss and tooth loss. As discussed previously, it may also lead to whole-body problems like heart disease, premature births, joint pain, and even Alzheimer's.

Now do the exact same thing with light pressure. The outcomes will be the same except it will take longer. However, my team has observed that the health consequences are the same. Why? Because the oral pathogens are able to travel outside of the mouth to other parts of your body and begin to multiply, causing disease. These organisms are opportunistic and they settle in places hospitable to their growth. The difference between, say, a heavy metal toxin and a bacterial toxin from the oral cavity, is that the bacteria can rapidly grow and multiply.


So many times, people I work with say "a just have a little occasional gum bleeding," or, I just have GERD or constipation occasionally. If you do, you are trending up the WRONG direction of the health-disease continuum.

If your gums bleed even just slightly or occasionally, you are actually experiencing vascular hemorrhages. Translation: your blood vessels have been weakened enough that even the mild pressure of flossing cleaves the vessel and blood escapes. This should NEVER happen.

In your mouth, you can witness this hemorrhaging. But what if this was happening in the vessels of your heart of your brain? I don't think anyone would want that. Enter the company Cortexyme. ¶

Cortexyme, Inc. (Nasdaq: CRTX), a clinical stage biopharmaceutical company pioneering a novel, disease-modifying therapeutic approach to treat what it believes to be a key underlying cause of Alzheimer's (AD) and other degenerative diseases, today announced the publication of research further documenting the ability of the pathogen Porphyromonas gingivalis to invade neurons and trigger Alzheimer's-like neuropathology. The findings are to be published in the June 2020 issue of the Journal of Alzheimer's Disease; an early online version of the paper is available now so that the important findings can be rapidly disseminated to the research community.

The market has spoken. Cortexyme is a public company with an admirable market cap. That means many people believe this company is on the right track. That is, the oral pathogen, P gingivalis, is a causal factor in Alzheimer's. And, of course, it comes from the mouth.


Just as an aside, my mentor at Harvard, Dr. Clement Trempe, spend much of his 47-year clinical career helping people understand the cause(s) of glaucoma and memory loss. In the past week, I have consulted with several people with both glaucoma and root canals, which in many cases were installed because of P. gingivalis and other oral pathogen. You see, glaucoma is Alzheimer's of the eye and Alzheimer's is glaucoma of the brain. They are caused by the exact same pathology. Sometimes we trace these diseases back to poor oral health. In other cases, it is caused by an organism like the pathogen from Lyme disease or chlamydia pneumoniae - both of which there are inexpensive tests to measure their presence and burden.


Here are some reference titles relating glaucoma and Alzheimer's

  • High occurrence rate of glaucoma among patients with Alzheimer's disease

  • Glaucoma: ocular Alzheimer's disease

  • Glaucoma, Alzheimer's disease, and Parkinson's disease: an 8-year population-based follow-up study

  • High frequency of open-angle glaucoma in Japanese patients with Alzheimer's disease

There are 115 such studies published in PubMed - the National Library of Medicine.


What can you do to treat or prevent the development or spread of oral pathogens?