Dr. Joe just published an excellent article on insulin resistance.
He states that you want your fasting insulin value below 3 for optimal metabolic health and flexibility. We have set an upper limit of 4 based on mortality studies. Mercola also states that his last test revealed his value was ~1.5 - truly optimal.
Bale & Doneen offers a valuable cardiometabolic program. Dr. Trempe and I met with them about 12 years ago and explained our program. Particularly, we explained that when your insulin is elevated, and the sugars follow - so do infections. They love sugars. Thomas Seyfried, Professor of Biology at BU, became the world expert on sugars and cancers. Here is a summary of his initiatives.
"Our research program focuses on mechanisms by which metabolic therapy manages chronic diseases such as epilepsy, neurodegenerative lipid storage diseases, and cancer. The metabolic therapies include caloric restriction, fasting, and ketogenic diets. Our approach is based on the idea that compensatory metabolic pathways can modify the pathogenesis of complex diseases. Global shifts in the metabolic environment can neutralize molecular pathology. In the case of cancer, these therapies target and kill tumor cells while enhancing the physiological health of normal cells. The neurochemical and genetic mechanisms of these phenomena are under investigation in novel animal models and include the processes of inflammation, cellular physiology, angiogenesis, and lipid biochemistry."
Tying this together, Dr. Carter and I wrote a book titled, "Cancer IS an infectious disease." Note we did NOT say "IS ONLY an infectious disease." There is an important distinction there.
Back to Bale and Doneen. Dr. Trempe asked them why the fasting insulin test was not front-and-center in their program. Dr. Mercola ONLY mentions the fasting insulin test. Instead, here are some 2023 excerpts from the Bale and Doneen program.
"A wide waist is the no. 1 warning sign of IR–even if you’re not overweight."
"The ADA rates the 2-hour oral glucose tolerance test (OGTT), in which you drink a sugary liquid after an overnight fast, as the “gold standard” in accuracy."
"Several studies show that the A1c test, which doesn’t require fasting, is unreliable for detecting IR/prediabetes." They claim the A1C gives false positives. Indeed, it does. If you are improving your diet and health, A1C, a backwards-looking marker is last to adjust downward (and, in diabetes, it is the last to adjust upward.)
"Other potential tipoffs that you may be insulin resistant include having high triglycerides combined with low levels of HDL (good) cholesterol, high blood pressure, sleep deficiency (averaging less than 6 hours a night triples risk for prediabetes), and periodontal (gum) disease."
I am involved with an organization that has a Bale and Doneen practitioner. How does this person measure insulin resistance? With the triglycerides to HDL ratio and NOT the fasting insulin test, even though both are of trivial cost and are acquired the same way - through a blood sample.
It's mind-boggling how even very smart people cannot go outside of their swim lane. It is defined as the "not invented here" syndrome.
BTW, they are wrong about the hidden cause of most heart attacks. It is actually sub-acute infections caused by elevated sugars and the myriad of other risks in people who do not pay close attention to their diet and their health in general.
I am not suggesting that the Bale and Doneen method is not beneficial. However, when a group cannot move from something as simple as the triglycerides/HDL ratio test to the actual direct measurement of insulin resistance - fasting insulin - what else are they missing or avoiding?
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